Vasudev Bailey, PhD, Zoe Guttendorf, ARTIS VENTURES
Scientists, clinicians, and researchers across the globe are working tirelessly to fight the pandemic, focusing efforts on three main areas of development:
It’s very encouraging to see efforts emerging from every pocket of the world as we all strive to fight this pandemic on a global scale, and all three categories already have significant work both in development, and in the preclinical pipeline.
We have compiled an innovation tracker at www.av.co/covid to keep tabs on the progress. We will keep this updated regularly.
DIAGNOSTICS
The diagnostics innovation and approval is fortunately a long list, which makes the market quite fragmented. We chatted with a few provider leaders, looking to ascertain if there was a leading market choice, with the resulting takeaway being that they were less concerned about timeliness of test results, and more concerned (rightfully so, perhaps) about sensitivity of these tests. This means they want to ensure there are limited “false negatives” (bottom left quadrant) - people who actually DO have COVID-19 but think they don’t and ignore social distancing and quarantine directives, thus spreading the virus to others.
In the world of diagnostics, while there are several products in development, our focus was to rely on data from regulatory bodies to help ensure that the sensitivity of the tests isn't compromised. Our data was determined by:
While we don’t have a good sense of the real world sensitivity and specificity of these diagnostics tests, what is clear is that there is no gold standard test, and many of these tests listed below are used across the world depending on what reagents are available and what machines (if PCR based) they have available
For a full list of diagnostics, click here: www.av.co/covid-diagnostics
The likelihood is that of all the innovations to fight this pandemic, the biggest impact that can be made will be from a pharma/biotech company that has an agent that is able to prevent viral growth, reduce hospitalization, reduce complications from having been infected, or will cure the person afflicted with COVID-19. As the world drug developers put their heads down and work on this solution, a creative path here has been the use of repurposed drugs that may prove to be efficacious in treating COVID-19.
For a full list of drugs and therapies that are in human trials, click here: https://www.av.co/covid-treatments
It is highly unlikely that a commercially viable vaccine will be ready over the next six months, or even in the next year. While Moderna seems to lead the pack in the US and a modified BCG vaccine is being developed in Europe and Australia, all claim that they may have a vaccine this summer. The challenge though isn’t as quite easy as they describe and even iIf successful, may only be available to at-risk health workers first. The development of a quick vaccine will require rapidly overcoming a variety of solutions from understanding immunological response and identifying antigens that generate protective response (easier challenges with technology, data and AI) to solving pathogen variability, variable genetic response, functional response, short effector memory or environmental factors and response (harder challenges due to lack of data and tools to be predictive and the need for real world evidence).
For a full list of vaccines that are in human testing, click here: www.av.co/covid-vaccines
LET’S KEEP THIS GOING!
We have worked to compile the available diagnostics as well as the vaccines and therapies/drugs that are currently in patient trials. We're also keeping an eye on early clinical projects. We'll be updating www.av.co/covid regularly. Please message us if you are aware of any other projects/studies not included here. We are optimistic that the healthcare community at large will come together to find an end to COVID-19.
Resource list available upon request.
Infographics designed by Iliana Marks.